Description

1(3H)-Isobenzofuranone, 3-Butyl-, (S)- is a chiral, non-racemic lactone derivative of significant interest in advanced organic synthesis. This compound serves as a valuable chiral building block and intermediate for the production of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Its specific stereochemistry and functional group make it essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), fine chemicals, and specialty materials where optical purity is critical.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure drugs and bioactive molecules.
• Agrochemical Synthesis: Building block for creating chiral pesticides, herbicides, and plant growth regulators.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Asymmetric Catalysis Research: Valuable substrate or ligand precursor in the development of new catalytic methodologies.
• Material Science: Intermediate for synthesizing chiral polymers or liquid crystals with specific optical properties.
• Academic & R&D: Standard for method development and chemical research in university and industrial laboratories.

Basic Information

Product Name	1(3H)-Isobenzofuranone, 3-Butyl-, (S)-
CAS No.	3413-15-8
Molecular Formula	C₁₂H₁₄O₂
Molecular Weight	190.24 g/mol
Synonyms	(S)-3-Butylphthalide; (S)-3-Butyl-1(3H)-isobenzofuranone; (S)-3-Butyl-3H-isobenzofuran-1-one; (S)-Butylphthalide; L-3-Butylphthalide; (S)-NBP; Senkyunolide I (related natural product); (3S)-3-Butyl-3H-2-benzofuran-1-one
EINECS	Contact for details

Quality Control

Our production of (S)-3-Butylphthalide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high optical purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (ee), and impurity profile is provided with every shipment. We support compliance with cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Optical Rotation [α]	Specific range provided on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.