Description

Cyclobutane-1,2-Dicarboxylic Acid CAS NO 3396-14-3 is a high-purity, versatile alicyclic dicarboxylic acid building block. This compound is valued for its unique strained four-membered ring structure, which imparts specific reactivity and conformational properties for advanced chemical synthesis. It is primarily utilized by pharmaceutical, agrochemical, and specialty polymer research and development teams seeking to create novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where its rigid structure can enhance biological activity and environmental stability.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for producing high-performance polyamides, polyesters, and coatings with tailored thermal and mechanical properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create chelating ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: A precursor for synthesizing complex flavors, fragrances, and other high-value specialty chemicals.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic synthesis and material science due to its unique cyclobutane backbone.

Basic Information

Product Name	Cyclobutane-1,2-Dicarboxylic Acid
CAS No.	3396-14-3
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol
Synonyms	1,2-Cyclobutanedicarboxylic Acid; Cyclobutane-1,2-dicarboxylic acid; 1,2-CBDA; NSC 163022; trans-Cyclobutane-1,2-dicarboxylic Acid; cis-Cyclobutane-1,2-dicarboxylic Acid; (±)-trans-1,2-Cyclobutanedicarboxylic Acid; 1,2-Dicarboxycyclobutane
EINECS	222-249-1

Quality Control

Our Cyclobutane-1,2-Dicarboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.