Description

Tetrahydrothiophen-3-Yl 4-Methylbenzenesulfonate is a high-purity sulfonate ester derivative, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules, particularly in the development of pharmaceuticals and specialty chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for their synthetic pathways.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing functionalized tetrahydrothiophene or sulfonate ester motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the sulfonate group acts as a good leaving group in substitution reactions.
• Material Science Research: Employed in the development of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Can serve as a reagent for bioconjugation or as a building block for activity-based probes in biochemical research.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry, including studies on sulfonate ester reactivity and ring-forming reactions.

Basic Information

Product Name	Tetrahydrothiophen-3-Yl 4-Methylbenzenesulfonate
CAS No.	3334-01-8
Molecular Formula	C11H14O3S2
Molecular Weight	258.36 g/mol
Synonyms	3-Tetrahydrothienyl p-Toluenesulfonate; Tetrahydrothiophen-3-yl Tosylate; 4-Methylbenzenesulfonic Acid Tetrahydrothiophen-3-yl Ester; 3-Thiolanyl Tosylate; p-Toluenesulfonic Acid Tetrahydro-3-thienyl Ester; Tetrahydro-3-thienyl p-Toluenesulfonate; THT-OTs; 3334-01-8
EINECS	Contact for details

Quality Control

Our Tetrahydrothiophen-3-Yl 4-Methylbenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the exacting standards required for research and commercial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.