Description

1-(p-Tosyloxy)-3-Pentyne is a specialized organic building block featuring a terminal alkyne group protected by a tosylate leaving group. This bifunctional molecular architecture makes it a valuable intermediate for constructing complex molecules via cross-coupling and nucleophilic substitution reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of active pharmaceutical ingredients (APIs) and bioactive molecules, particularly those requiring alkyne functionalization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Building block for polymers, dendrimers, and liquid crystals where the alkyne group enables click chemistry or other polymerization strategies.
• Organic Synthesis & Research: Versatile reagent for Sonogashira coupling, alkylation reactions, and as a protected alkyne precursor in multi-step synthetic routes.
• Chemical Biology Probes: Useful for labeling biomolecules or creating probes via bioorthogonal reactions like copper-catalyzed azide-alkyne cycloaddition (CuAAC).

Basic Information

Product Name	1-(p-Tosyloxy)-3-Pentyne
CAS No.	3329-88-2
Molecular Formula	C₁₂H₁₄O₃S
Molecular Weight	238.30 g/mol
Synonyms	3-Pentyn-1-yl 4-methylbenzenesulfonate; 3-Pentynyl tosylate; 1-Tosyloxy-3-pentyne; p-Toluenesulfonic acid 3-pentynyl ester; 4-Methylbenzenesulfonic acid 3-pentynyl ester; 3-Pentynyl p-toluenesulfonate; Tosyloxy-3-pentyne
EINECS	Contact for details

Quality Control

Our 1-(p-Tosyloxy)-3-Pentyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.