Description

2-Chlorotetrahydro-2H-Pyran is a versatile chlorinated heterocyclic building block, primarily valued for its reactivity as an alkylating agent and its role as a protected form of 5-chloropentanal. This compound matters because it provides a critical synthetic handle for constructing complex molecules in pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for applications ranging from nucleoside chemistry to the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediates: Key building block in the synthesis of nucleoside analogs and other complex heterocyclic APIs.
• Agrochemical Synthesis: Used in the production of certain herbicides and fungicides as a chlorinated synthon.
• Fine Chemical Manufacturing: Serves as a versatile alkylating agent in multi-step organic synthesis for specialty chemicals.
• Polymer Chemistry: Potential monomer or modifier in the development of specialized polymeric materials.
• Cross-coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed coupling reactions.
• Protecting Group Chemistry: The tetrahydropyranyl group can be used to protect alcohols, with the chlorine allowing for further functionalization.

Basic Information

Product Name	2-Chlorotetrahydro-2H-Pyran
CAS No.	3136-02-5
Molecular Formula	C5H9ClO
Molecular Weight	120.58 g/mol
Synonyms	2-Chlorotetrahydropyran; 2-Chlorooxane; 5-Chloropentanal, cyclic acetal; 2-Chloro-1-oxaspiro[2.5]octane (incorrect but sometimes listed); α-Chlorotetrahydropyran; Tetrahydro-2H-pyran-2-yl chloride; 2-Chloro-tetrahydropyran; 2-Chlorooxacyclohexane
EINECS	221-527-8

Quality Control

Our 2-Chlorotetrahydro-2H-Pyran is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP standards for production intended for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at room temperature for shorter periods. Keep container tightly sealed to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.10 - 1.15 g/mL
Refractive Index (n20D)	1.455 - 1.465

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.