Description

2,2-Diphenylglycine is a high-purity, non-proteinogenic amino acid derivative characterized by its two phenyl substituents on the alpha carbon. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, valued for its structural rigidity and potential for introducing steric bulk. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for applications in asymmetric synthesis, peptide mimetics, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Asymmetric Catalyst Ligand Precursor: Used in the synthesis of specialized ligands for metal-catalyzed asymmetric reactions, enhancing enantioselectivity.
• Peptidomimetic Scaffold: Incorporated into peptide analogs to improve metabolic stability and bioavailability by mimicking natural peptide structure.
• Academic & Industrial Research: Serves as a standard or starting material in methodological development and structure-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex organic molecules requiring diphenylglycine motifs.

Basic Information

Product Name	2,2-Diphenylglycine
CAS No.	3060-50-2
Molecular Formula	C14H13NO2
Molecular Weight	227.26 g/mol
Synonyms	α-Aminodiphenylacetic Acid; Diphenylglycine; 2-Amino-2,2-diphenylacetic Acid; NSC 3349; (Aminodiphenyl)acetic Acid; DPG; 2,2-Diphenyl-2-aminoacetic Acid; α,α-Diphenylglycine
EINECS	221-300-5

Quality Control

Our 2,2-Diphenylglycine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets exacting standards for research and production use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.