Description

2-(Trifluoromethyl)Benzylamine is a versatile aromatic amine building block characterized by a reactive primary amine group and a highly electron-withdrawing trifluoromethyl substituent. This unique structure makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules, which is a key requirement in modern pharmaceutical and agrochemical design. It is essential for research chemists and process development scientists in the life sciences and advanced materials sectors seeking to enhance compound properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS, antiviral, and anticancer drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the CF₃ group improves bioavailability and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for electron-transport materials and alignment layers in display technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter surface properties, thermal stability, and chemical resistance.
• Organic Synthesis Reagent: Employed in peptide coupling reactions and as a precursor for heterocyclic compounds like benzimidazoles and quinazolines.
• Catalyst Ligand Precursor: Used to synthesize chiral amine ligands for asymmetric catalysis in fine chemical production.

Basic Information

Product Name	2-(Trifluoromethyl)Benzylamine
CAS No.	3048-01-9
Molecular Formula	C₈H₈F₃N
Molecular Weight	175.15 g/mol
Synonyms	α-(Trifluoromethyl)benzylamine; (2-Trifluoromethylphenyl)methanamine; 2-(Trifluoromethyl)phenylmethylamine; 1-[2-(Trifluoromethyl)phenyl]methanamine; 2-(Trifluoromethyl)benzenemethanamine; α,α,α-Trifluoro-o-toluidine; o-(Trifluoromethyl)benzylamine; 2-CF3-Benzylamine
EINECS	221-264-5

Quality Control

Our 2-(Trifluoromethyl)Benzylamine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Gravity (20°C)	1.25 - 1.30
Refractive Index (n20/D)	1.470 - 1.480

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.