Description

1-Bromo-2,5-Difluorobenzene is a high-purity halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a versatile intermediate for introducing specific reactivity and electronic properties into target molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the difluorobenzene moiety contributes to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations, enabling complex molecule assembly.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and developing new fluorination methodologies in academic and industrial R&D.
• Polymer Modification: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, or specific optical properties.

Basic Information

Product Name	1-Bromo-2,5-Difluorobenzene
CAS No.	399-94-0
Molecular Formula	C6H3BrF2
Molecular Weight	192.99 g/mol
Synonyms	2,5-Difluorobromobenzene; 2-Bromo-1,4-difluorobenzene; 1,4-Difluoro-2-bromobenzene; Benzene, 1-bromo-2,5-difluoro-; 2,5-Difluorophenyl bromide; Bromo-2,5-difluorobenzene; (2,5-Difluorophenyl)bromide
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,5-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%
Density (at 20°C)	~1.7 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.