Description

2-(Trifluoromethyl)Benzamide is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the unique properties imparted by the trifluoromethyl group, which is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the CF₃ group enhances biological activity and environmental persistence.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing character and thermal stability.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and enzyme inhibitors to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for bespoke synthesis projects requiring fluorinated aromatic compounds.

Basic Information

Product Name	2-(Trifluoromethyl)Benzamide
CAS No.	360-64-5
Molecular Formula	C₈H₆F₃NO
Molecular Weight	189.14 g/mol
Synonyms	2-(Trifluoromethyl)benzamide; o-(Trifluoromethyl)benzamide; α,α,α-Trifluoro-o-toluamide; Benzamide, 2-(trifluoromethyl)-; 2-Trifluoromethylbenzamide; 2-Carbamoylbenzotrifluoride; o-Trifluoromethylbenzamide; 2-(Trifluoromethyl)benzenecarboxamide
EINECS	206-632-5

Quality Control

Our 2-(Trifluoromethyl)Benzamide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports your regulatory needs for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. The product is stable under recommended conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.