Description

2,2,2-Trifluoroethoxysulfonylbenzene is a specialized organofluorine building block featuring a sulfonyl group adjacent to a trifluoroethoxy moiety. This unique structure makes it a valuable reagent for introducing the trifluoroethoxysulfonyl group into target molecules, enabling the synthesis of novel compounds with modified electronic and steric properties. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and as a precursor for advanced intermediates.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide derivatives or modifying drug solubility and metabolic stability.
• Agrochemical Synthesis: Serves as a key building block for developing new herbicides, fungicides, or insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, or organic electronic materials where the sulfonyl and fluorine groups impart specific physical characteristics.
• Chemical Biology Probes: Utilized as a reagent for labeling or modifying biomolecules in proteomics and biochemical research due to its reactive sulfonyl chloride precursor potential.
• Organic Synthesis Reagent: Acts as a versatile electrophile in nucleophilic substitution reactions or as a protecting group precursor in complex multi-step synthetic routes.

Basic Information

Product Name	2,2,2-Trifluoroethoxysulfonylbenzene
CAS No.	339-48-0
Molecular Formula	C8H7F3O3S
Molecular Weight	240.20 g/mol
Synonyms	Benzene, 1-[(2,2,2-trifluoroethoxy)sulfonyl]-; 1-(Trifluoroethoxysulfonyl)benzene; α,α,α-Trifluoroethyl phenyl sulfonate; Phenyl 2,2,2-trifluoroethyl sulfonate; Trifluoroethyl benzenesulfonate; 2,2,2-Trifluoroethyl phenylsulfonate; Benzenesulfonic acid 2,2,2-trifluoroethyl ester
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoroethoxysulfonylbenzene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support custom synthesis and can tailor purity grades to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider using an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.