Description

Methyl Trifluoromethanesulfonate (CAS NO 333-27-7) is a highly reactive methylating and triflating agent, prized for its powerful electrophilic properties. This compound is a critical reagent in advanced organic synthesis, enabling the efficient introduction of methyl and trifluoromethanesulfonyl groups under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for constructing complex molecules, synthesizing active pharmaceutical ingredients (APIs), and developing novel materials.

Application

• Pharmaceutical Synthesis: A key reagent for the methylation of heterocycles, alcohols, phenols, and amines in the production of active pharmaceutical ingredients (APIs) and intermediates.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides where the introduction of a methyl group or a triflate leaving group is required.
• Polymer & Material Science: Serves as an initiator or functionalization agent in the production of specialty polymers, ionic liquids, and advanced materials.
• Organic Synthesis & Methodology: Employed as a potent electrophile in Friedel-Crafts alkylations, esterifications, and the synthesis of complex natural products.
• Chemical Research & Development: A versatile tool in laboratory-scale reactions for exploring new synthetic pathways and creating novel chemical entities.
• Fine Chemical Production: Utilized in the manufacture of dyes, flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	Methyl Trifluoromethanesulfonate
CAS No.	333-27-7
Molecular Formula	C2H3F3O3S
Molecular Weight	164.10 g/mol
Synonyms	Methyl Triflate; Trifluoromethanesulfonic Acid Methyl Ester; Methyl Trifluoromethylsulfonate; Methyl Trifluoromethanesulphonate; Methyl Perfluoroalkanesulfonate; Methyl Ester of Triflic Acid; CF3SO3CH3; Methyl Trifluoromethanesulfonate (Methyl Triflate)
EINECS	206-370-6

Quality Control

Our Methyl Trifluoromethanesulfonate is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and nucleophiles.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total
Density (at 20°C)	1.45 - 1.50 g/mL
Refractive Index (n20D)	1.325 - 1.335

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.