Description

(R)-2-(Benzo[B]Thiophen-2-Yl)-4-(tert-Butyl)-4,5-Dihydrooxazole is a high-value chiral oxazoline derivative, a crucial building block in modern asymmetric synthesis and pharmaceutical development. Its significance lies in its role as a versatile ligand precursor and chiral auxiliary, enabling the production of enantiomerically pure compounds with high stereoselectivity. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and oncological disorders.
• Asymmetric Catalysis: Serves as a precursor for chiral oxazoline ligands used in transition metal-catalyzed reactions like cyclopropanations and Diels-Alder reactions.
• Agrochemical Research: Intermediate in the development of novel, enantiomerically pure herbicides and fungicides.
• Material Science: Used in the synthesis of chiral polymers and liquid crystals for optoelectronic applications.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and catalysis studies at universities and corporate R&D centers.
• Process Chemistry: Employed in scaling up enantioselective manufacturing processes from laboratory to pilot plant scale.

Basic Information

Product Name	(R)-2-(Benzo[B]Thiophen-2-Yl)-4-(tert-Butyl)-4,5-Dihydrooxazole
CAS No.	2757084-01-6
Molecular Formula	C₁₅H₁₇NOS
Molecular Weight	259.37 g/mol
Synonyms	(R)-2-(Benzo[b]thiophen-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole; (R)-2-(1-Benzothiophen-2-yl)-4-(tert-butyl)-2-oxazoline; (R)-4-(tert-Butyl)-2-(benzo[b]thiophen-2-yl)-4,5-dihydrooxazole; (R)-2-(2-Benzo[b]thienyl)-4-(1,1-dimethylethyl)-4,5-dihydrooxazole; (R)-t-Bu-Box-Benzothiophene; Chiral Benzothiophene Oxazoline; (R)-Benzothiophene-tert-Butyl-Oxazoline
EINECS	Contact for details

Quality Control

Every batch of (R)-2-(Benzo[B]Thiophen-2-Yl)-4-(tert-Butyl)-4,5-Dihydrooxazole is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, and chiral analysis to ensure high enantiomeric excess (ee) and chemical purity, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) with full chromatographic data are provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.