Description

1-Amino-3,6,9,12-Tetraoxapentadecan-15-Oic Acid Hydrochloride is a specialized polyethylene glycol (PEG) derivative, serving as a critical bifunctional linker for advanced bioconjugation and pharmaceutical development. This compound matters because it provides a hydrophilic spacer arm with a terminal carboxylic acid and a primary amine, enabling precise covalent attachment between molecules in aqueous environments. It is essential for researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced material science who require reliable, high-purity building blocks for creating targeted drug conjugates, peptide modifications, and functionalized surfaces.

Application

• Bioconjugation Linker: Used to covalently attach drugs, dyes, or other functional molecules to proteins, antibodies, or peptides, improving solubility and pharmacokinetics.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key component in the synthesis of linker-payload constructs for targeted cancer therapies.
• PEGylation Reagent: Acts as a heterobifunctional PEG spacer to modify biomolecules, reducing immunogenicity and increasing circulation half-life.
• Diagnostic Probe Synthesis: Utilized in the preparation of contrast agents or fluorescent probes for imaging applications.
• Polymer Chemistry: Functions as a monomer or chain extender for creating functionalized, water-soluble polymers and hydrogels.
• Surface Functionalization: Applied to modify nanoparticles, chips, or other materials to introduce amine or carboxyl groups for further coupling.
• Cross-linking Agent: Employed in the formation of stable cross-links between molecules in biochemical assays or material scaffolds.
• Intermediate for Fine Chemicals: Used as a high-value synthetic intermediate in custom organic synthesis for research and development.

Basic Information

Product Name	1-Amino-3,6,9,12-Tetraoxapentadecan-15-Oic Acid Hydrochloride
CAS No.	2708292-39-9
Molecular Formula	C11H23ClNO7
Molecular Weight	316.76 g/mol
Synonyms	15-Amino-4,7,10,13-tetraoxapentadecanoic Acid Hydrochloride; Fmoc-NH-PEG4-CH2CH2COOH HCl; N-(Fmoc)-8-amino-3,6-dioxaoctanoic Acid (PEG4 derivative) HCl; Heterobifunctional PEG4 Acid Amine HCl; α-Amino-ω-carboxy tetraethylene glycol hydrochloride; Amino-PEG4-acid hydrochloride; 2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]acetic Acid Hydrochloride; Fmoc-N-amido-PEG4-acid HCl
EINECS	Contact for details

Quality Control

Our 1-Amino-3,6,9,12-Tetraoxapentadecan-15-Oic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical and bioconjugation applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Long-term storage is recommended at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.