Description

5-[[2-(2-Aminoethoxy)Ethyl]Amino]-2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione is a high-purity, advanced pharmaceutical intermediate belonging to the isoindole-1,3-dione class of compounds. This compound is of significant commercial interest due to its role as a key building block in the synthesis of novel targeted protein degraders, such as Proteolysis-Targeting Chimeras (PROTACs). It is primarily required by pharmaceutical R&D organizations, biotechnology companies, and fine chemical manufacturers engaged in the development of next-generation therapeutic agents.

Application

• PROTAC (Proteolysis-Targeting Chimera) Development: Serves as a critical linker-warhead component connecting an E3 ligase ligand to a target protein binder.
• Biopharmaceutical Research: Used in the discovery and optimization of novel small-molecule degraders for oncology, neurodegenerative, and inflammatory diseases.
• Chemical Biology Probes: Employed in the synthesis of molecular tools for studying ubiquitin-proteasome system (UPS) pathways and protein function.
• Preclinical Candidate Synthesis: A key raw material in the scale-up synthesis of drug candidates for IND-enabling studies.
• Custom Synthesis Services: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.

Basic Information

Product Name	5-[[2-(2-Aminoethoxy)Ethyl]Amino]-2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione
CAS No.	2412056-16-5
Molecular Formula	C19H23N5O5
Molecular Weight	401.42 g/mol
Synonyms	5-((2-(2-Aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Thalidomide-PEG2-amine derivative; E3 Ligase Ligand-PEG2-NH2; PROTAC Linker-Warhead Intermediate; Lenalidomide-PEG2-amine analog; (S)-5-((2-(2-Aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Cereblon Ligand-PEG2-Amine
EINECS	Contact for details

Quality Control

Our 5-[[2-(2-Aminoethoxy)Ethyl]Amino]-2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, chiral analysis, and comprehensive identification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.