Description

Tco-Peg2-Sulfo-Nhs Ester is a heterobifunctional crosslinking reagent featuring a cleavable TCO (trans-cyclooctene) group and a hydrophilic, sulfonated NHS ester. This compound is engineered to enable efficient, site-specific bioconjugation under mild, aqueous conditions, making it invaluable for advanced life science research and therapeutic development. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and bioorthogonal chemistry for labeling and linking biomolecules.

Application

• Bioorthogonal Labeling: Site-specific conjugation of peptides, proteins, and antibodies via the TCO-tetrazine inverse electron-demand Diels-Alder (IEDDA) click reaction.
• Antibody-Drug Conjugate (ADC) Synthesis: Facilitating the development of next-generation ADCs by providing a cleavable, hydrophilic linker-payload attachment strategy.
• Proteomics & Biomarker Discovery: Immobilization or tagging of biomolecules for pull-down assays, mass spectrometry, and diagnostic applications.
• Surface Functionalization: Modification of nanoparticles, biosensors, and microarray surfaces to create bioactive interfaces.
• Fluorescent Probe & Imaging Agent Conjugation: Attachment of dyes, radiolabels, or contrast agents for in vitro and in vivo imaging studies.
• Polymer & Biomaterial Modification: Introducing bio-recognition elements into hydrogels and polymeric scaffolds for tissue engineering.

Basic Information

Product Name	Tco-Peg2-Sulfo-Nhs Ester
CAS No.	2353409-48-8
Molecular Formula	C₂₃H₃₀N₂O₁₂S₂
Molecular Weight	590.62 g/mol
Synonyms	trans-Cyclooctene-PEG2-Sulfo-NHS Ester; TCO-PEG2-S-Sulfo-NHS; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-((2,5-dioxopyrrolidin-1-yl)oxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-yl) sulfamate; Sulfo-NHS ester of TCO-PEG2-amine; TCO-PEG2-Sulfo-NHS; Heterobifunctional TCO linker; TCO-Sulfo-NHS Crosslinker
EINECS	Contact for details

Quality Control

Our Tco-Peg2-Sulfo-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.