Description

5,5-Difluorotetrahydro-2H-Pyran-3-Amine Hydrochloride is a high-purity fluorinated amine building block essential for modern pharmaceutical and agrochemical research. Its value lies in its unique difluorinated tetrahydropyran scaffold, which is prized for modulating the physicochemical properties and metabolic stability of bioactive molecules. This compound is a critical intermediate for medicinal chemists and process development scientists working on novel drug candidates, particularly in CNS and metabolic disease research.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting protease and kinase enzymes.
• Agrochemical Research: Used in the development of advanced herbicides and fungicides, where the fluorine atoms enhance bioavailability and environmental persistence.
• Chemical Biology Probes: Serves as a precursor for fluorinated molecular probes used in studying enzyme mechanisms and protein-ligand interactions.
• Material Science: Potential monomer or modifier in the synthesis of specialty polymers with unique surface properties.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP manufacturing of complex molecules.

Basic Information

Product Name	5,5-Difluorotetrahydro-2H-Pyran-3-Amine Hydrochloride
CAS No.	2306275-99-8
Molecular Formula	C5H10ClF2NO
Molecular Weight	185.59 g/mol
Synonyms	3-Amino-5,5-difluorotetrahydropyran hydrochloride; 5,5-Difluoro-3-aminotetrahydropyran HCl; 5,5-Difluoro-3-aminotetrahydro-2H-pyran hydrochloride; 5,5-Difluoro-3-pyranamine hydrochloride; 3-Amino-5,5-difluorooxane hydrochloride; 5,5-Difluoro-3-aminooxane hydrochloride; 2306275-99-8
EINECS	Contact for details

Quality Control

Every batch of 5,5-Difluorotetrahydro-2H-Pyran-3-Amine Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.