Description

7-(((1R,2S)-2-Aminocyclohexyl)Amino)-4-Oxo-5-(m-Tolylamino)-3,4-Dihydropyrido[3,4-D]Pyridazine-8-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its potential as a key building block in kinase inhibitor synthesis. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel therapeutic agents for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.
• Biochemical Tool Compound: Employed in vitro and in vivo to study specific biological pathways and validate novel drug targets.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	7-(((1R,2S)-2-Aminocyclohexyl)Amino)-4-Oxo-5-(m-Tolylamino)-3,4-Dihydropyrido[3,4-D]Pyridazine-8-Carbonitrile
CAS No.	2304654-43-9
Molecular Formula	C21H23N7O
Molecular Weight	389.46 g/mol
Synonyms	7-(((1R,2S)-2-Aminocyclohexyl)amino)-5-((3-methylphenyl)amino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazine-8-carbonitrile; (1R,2S)-N1-(8-Cyano-5-((3-methylphenyl)amino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-7-yl)cyclohexane-1,2-diamine; 7-((2-Aminocyclohexyl)amino)-5-(m-tolylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazine-8-carbonitrile (stereoisomer); CAS 2304654-43-9; Kinase Inhibitor Intermediate; Pyridopyridazine derivative
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research and development applications. Our quality system includes comprehensive analytical characterization using HPLC, LC-MS, and 1H/13C NMR to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support compliance with cGMP standards for advanced intermediates as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0%
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.