Description

(R)-3-(Adamantan-1-Yl)-1-(2-Hydroxy-1-Phenylethyl)-4,5-Dihydro-1H-Imidazol-3-Ium Hexafluorophosphate(V) CAS NO 2281885-69-4 is a high-purity, chiral imidazolium salt featuring an adamantyl group and a phenylethanol-derived substituent. This compound is a valuable advanced pharmaceutical intermediate and specialty ligand for asymmetric synthesis and catalysis. It is primarily required by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and fine chemical sectors for developing novel active ingredients and chiral catalysts.

Application

• Chiral Catalyst Precursor: Serves as a key building block for synthesizing novel N-heterocyclic carbene (NHC) ligands used in asymmetric metal-catalyzed reactions like cross-coupling and hydrogenation.
• Pharmaceutical Intermediate: Employed in the research and development of new drug candidates, particularly those targeting neurological or metabolic disorders where the adamantyl moiety is pharmacologically relevant.
• Organocatalyst Synthesis: Used to create sophisticated imidazolinium-based organocatalysts for enantioselective synthesis in fine chemical production.
• Agrochemical Research: Acts as an intermediate in developing new, more selective pesticides and herbicides with complex stereochemistry.
• Material Science: Investigated for the preparation of ionic liquids or functionalized materials with specific chiral recognition properties.
• Academic & Industrial R&D: A critical reagent for methodological studies in organic chemistry and process development for scale-up.

Basic Information

Item	Details
Product Name	(R)-3-(Adamantan-1-Yl)-1-(2-Hydroxy-1-Phenylethyl)-4,5-Dihydro-1H-Imidazol-3-Ium Hexafluorophosphate(V)
CAS No.	2281885-69-4
Molecular Formula	C21H28F6N2OP
Molecular Weight	484.43 g/mol
Synonyms	(R)-1-(2-Hydroxy-1-phenylethyl)-3-(1-adamantyl)-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate; (R)-3-Adamantyl-1-(2-hydroxy-1-phenylethyl)-4,5-dihydro-1H-imidazol-3-ium PF6; Chiral Adamantyl Imidazolinium Hexafluorophosphate; (R)-Ad-Imd-PF6; (R)-1-(1-Hydroxy-1-phenylpropan-2-yl)-3-tricyclo[3.3.1.1³,⁷]dec-1-yl-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate
EINECS	Contact for details

Quality Control

Our (R)-3-(Adamantan-1-Yl)-1-(2-Hydroxy-1-Phenylethyl)-4,5-Dihydro-1H-Imidazol-3-Ium Hexafluorophosphate(V) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and tests for residual solvents and moisture to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.