Description

(2S)-1-[(4R)-4,5-Dihydro-4-Phenylmethyl-2-Oxazolyl]-2-(Diphenylphosphino)Ferrocene is a highly specialized chiral ferrocenyl phosphine-oxazoline ligand, a critical component in asymmetric catalysis. Its value lies in enabling precise stereochemical control in transition metal-catalyzed reactions, which is essential for producing enantiomerically pure intermediates in pharmaceutical and fine chemical synthesis. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications such as asymmetric hydrogenation and C-C bond formation.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiopure pharmaceutical intermediates.
• Catalyst component for asymmetric C-C bond-forming reactions, including allylic alkylation and Heck reactions.
• Key reagent in the development of stereoselective synthetic routes for complex natural products and active pharmaceutical ingredients (APIs).
• Use in academic and industrial research to explore new catalytic methodologies and optimize existing processes.
• Potential application in the synthesis of chiral agrochemicals and flavors & fragrances.
• As a reference standard for analytical method development and quality control in chiral chemistry.

Basic Information

Product Name	(2S)-1-[(4R)-4,5-Dihydro-4-Phenylmethyl-2-Oxazolyl]-2-(Diphenylphosphino)Ferrocene
CAS No.	2256046-71-4
Molecular Formula	C36H32FeNOP
Molecular Weight	557.47 g/mol
Synonyms	(S,R)-PF-Phox; (2S)-1-[(4R)-4,5-Dihydro-4-(phenylmethyl)-2-oxazolyl]-2-(diphenylphosphino)ferrocene; Ferrocenyl phosphine-oxazoline ligand PF-Phox; (S,R)-PF-Phox Ferrocene Ligand; PF-Phox Ligand; Chiral Ferrocenyl Phosphinooxazoline; (S,R)-2-[2-(Diphenylphosphino)ferrocenyl]-4-benzyl-4,5-dihydrooxazole
EINECS	Contact for details

Quality Control

Our production of (2S)-1-[(4R)-4,5-Dihydro-4-Phenylmethyl-2-Oxazolyl]-2-(Diphenylphosphino)Ferrocene adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analysis, including chiral HPLC, NMR, and elemental analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.