Description

Potassium Trifluoro({[4-(Trifluoromethyl)Phenyl]Methyl})Boranuide is a highly specialized organoboron reagent, specifically a potassium trifluoroborate salt, with the CAS number 2248620-16-6. This compound is valued for its exceptional stability and reactivity as a key building block in advanced synthetic chemistry, particularly in cross-coupling reactions. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant boronic acid equivalent for the synthesis of biaryl and heterobiaryl structures, which are core motifs in many active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: A critical precursor in the development of novel drug candidates, especially those containing trifluoromethylphenyl groups for enhanced metabolic stability and lipophilicity.
• Agrochemical Research: Used in the creation of new herbicides, fungicides, and insecticides where the introduction of specific fluorinated aromatic systems is required for bioactivity.
• Materials Science & OLED Development: Employed in the synthesis of organic semiconductors, liquid crystals, and light-emitting materials for electronic devices.
• Process Chemistry & Scale-up: Its improved handling characteristics compared to boronic acids make it suitable for optimizing and scaling up manufacturing processes under GMP conditions.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis of diverse compound libraries for screening in medicinal chemistry programs.

Basic Information

Product Name	Potassium Trifluoro({[4-(Trifluoromethyl)Phenyl]Methyl})Boranuide
CAS No.	2248620-16-6
Molecular Formula	C8H6BF6K
Molecular Weight	266.04 g/mol
Synonyms	Potassium (4-(Trifluoromethyl)benzyl)trifluoroborate; Potassium Trifluoro(4-(trifluoromethyl)benzyl)borate; [4-(Trifluoromethyl)benzyl]trifluoroborate Potassium Salt; (4-Trifluoromethylbenzyl)trifluoroboronic Acid Potassium Salt; Potassium (4-Trifluoromethylbenzyl)trifluoroboranuide; K-4-TFM-Bn-BF3; Potassium Benzyltrifluoroborate Derivative
EINECS	Contact for details

Quality Control

Our Potassium Trifluoro({[4-(Trifluoromethyl)Phenyl]Methyl})Boranuide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 11B, 19F), HPLC, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) to maintain stability and prevent decomposition. Keep away from strong acids and strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Elemental Analysis)	95 - 105%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.