Description

(4R)-7-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic interest. Its value lies in its defined stereochemistry and functional groups, which are crucial for constructing complex molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates.
• Organic Synthesis Building Block: Used for constructing complex heterocyclic frameworks in medicinal chemistry.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in studies of stereoselective transformations.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(4R)-7-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride
CAS No.	2241594-30-7
Molecular Formula	C9H11Cl2NO
Molecular Weight	220.10 g/mol
Synonyms	(4R)-7-Chloro-3,4-dihydro-2H-chromen-4-amine hydrochloride; (R)-7-Chloro-3,4-dihydro-2H-chromen-4-amine hydrochloride; (4R)-7-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine HCl; 7-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride (R-enantiomer); (R)-7-Chloro-3,4-dihydro-2H-1,4-benzoxazine-4-amine hydrochloride (tautomeric form); (R)-7-Chloro-4-aminochroman hydrochloride
EINECS	Contact for details

Quality Control

Our (4R)-7-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles. We support development and commercial projects with specifications that can meet GMP starting material requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.