Description

1-Chloro-4-Methanesulfonylbutan-2-One is a specialized organic building block featuring both a reactive chloro and a methanesulfonyl (mesyl) functional group. This unique bifunctional structure makes it a valuable intermediate for the synthesis of more complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel chemical entities and developing active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs.
• Chemical Synthesis Reagent: Serves as a versatile electrophile in alkylation and nucleophilic substitution reactions to introduce functionalized butanone moieties.
• Agrochemical Research: Used in the research and development of new pesticides and herbicides, leveraging its reactive sites for structural diversification.
• Material Science Precursor: Potential intermediate in the synthesis of specialty polymers or functional materials requiring specific sulfone or ketone linkages.
• Bioconjugation Chemistry: The chloro group can be utilized for linking molecules to carriers or surfaces in biochemical and diagnostic applications.
• Academic & Industrial R&D: A valuable tool compound for methodological development and exploring new reaction pathways in organic synthesis laboratories.

Basic Information

Product Name	1-Chloro-4-Methanesulfonylbutan-2-One
CAS No.	2228671-34-7
Molecular Formula	C5H9ClO3S
Molecular Weight	184.64 g/mol
Synonyms	4-(Methanesulfonyl)-1-chlorobutan-2-one; 1-Chloro-4-(methylsulfonyl)butan-2-one; 4-Methanesulfonyl-1-chlorobutan-2-one; 2-Butanone, 1-chloro-4-(methylsulfonyl)-; Chloromesylbutanone; Mesyl Chlorobutanone; CAS 2228671-34-7
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Methanesulfonylbutan-2-One is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.