Description

3-Phenylbicyclo[1.1.1]pentane-1-carboxamide is a high-value, synthetically challenging bicyclic building block featuring a unique [1.1.1]propellane core. This compound matters as a key intermediate for medicinal chemistry research, enabling the exploration of novel three-dimensional chemical space and the development of new pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery programs targeting CNS disorders, metabolic diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel active pharmaceutical ingredients (APIs) with improved metabolic stability and bioavailability.
• Medicinal Chemistry Research: Used in fragment-based drug discovery and lead optimization to introduce rigid, three-dimensional scaffolds into candidate molecules.
• Agrochemical Development: Serves as a precursor for creating new crop protection agents with unique modes of action.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for studying protein-ligand interactions and biological pathways.
• Advanced Material Synthesis: Potential precursor for specialty polymers and materials with tailored physical properties.
• Academic Research: Employed in methodological studies and the synthesis of complex natural product analogs in university and institutional labs.

Basic Information

Product Name	3-Phenylbicyclo[1.1.1]pentane-1-carboxamide
CAS No.	2227206-18-8
Molecular Formula	C12H13NO
Molecular Weight	187.24 g/mol
Synonyms	3-Phenylbicyclo[1.1.1]pentane-1-carboxylic acid amide; 3-Phenyl-1-carbamoylbicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentane-1-carboxamide, 3-phenyl-; 1-Carbamoyl-3-phenylbicyclo[1.1.1]pentane; 3-Phenyl-bicyclo[1.1.1]pentyl-1-carboxamide; [1.1.1]Propellane-3-phenyl-1-carboxamide; 2227206-18-8
EINECS	Contact for details

Quality Control

Our 3-Phenylbicyclo[1.1.1]pentane-1-carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports your research and development needs with reliable, high-purity materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.