Description

Methanesulfonic Acid, 1,1,1-Trifluoro-, 6-Bromo-3-Cyanopyrazolo[1,5-A]Pyridin-4-Yl Ester is a high-value, multifunctional chemical intermediate designed for advanced synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture in complex organic frameworks. It is primarily utilized in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials where its unique trifluoromethanesulfonate (triflate) ester group and heterocyclic core enable key coupling and functionalization reactions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly in medicinal chemistry for oncology and CNS-targeted therapies.
• Agrochemical Research: Used in creating novel pesticides and herbicides, leveraging the pyrazolopyridine scaffold for biological activity.
• Material Science: Serves as a precursor for advanced organic electronic materials, including OLEDs and charge-transport layers.
• Cross-Coupling Reactions: Acts as an excellent electrophile in Pd-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the reactive triflate leaving group.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of tailored, high-purity intermediates under cGMP conditions.

Basic Information

Product Name	Methanesulfonic Acid, 1,1,1-Trifluoro-, 6-Bromo-3-Cyanopyrazolo[1,5-A]Pyridin-4-Yl Ester
CAS No.	2222756-23-0
Molecular Formula	C10H3BrF3N3O3S
Molecular Weight	373.11 g/mol
Synonyms	6-Bromo-3-cyanopyrazolo[1,5-a]pyridin-4-yl trifluoromethanesulfonate; 4-Trifluoromethanesulfonyloxy-6-bromo-3-cyanopyrazolo[1,5-a]pyridine; 6-Bromo-3-cyano-4-(trifluoromethanesulfonyloxy)pyrazolo[1,5-a]pyridine; 6-Bromo-4-((trifluoromethyl)sulfonyloxy)-3-cyanopyrazolo[1,5-a]pyridine; Pyrazolo[1,5-a]pyridine-4-ol, 6-bromo-3-cyano-, trifluoromethanesulfonate; Triflate Ester of 6-Bromo-3-cyanopyrazolo[1,5-a]pyridin-4-ol
EINECS	Contact for details

Quality Control

Our Methanesulfonic Acid, 1,1,1-Trifluoro-, 6-Bromo-3-Cyanopyrazolo[1,5-A]Pyridin-4-Yl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, and custom synthesis can be performed to meet specific regulatory or research-grade requirements, including cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.