Description

Trifluoroacetic Acid CAS NO 2173637-40-4 is a highly versatile and potent fluorinated organic acid. It serves as a critical reagent and solvent in advanced organic synthesis and pharmaceutical manufacturing, valued for its strong acidity and excellent solvating properties. This compound is essential for industries requiring high-purity intermediates, including pharmaceuticals, agrochemicals, and specialty polymers.

Application

• Pharmaceutical Synthesis: A key reagent for peptide synthesis, deprotection of tert-butyl esters and carbamates, and as a solvent for HPLC.
• Agrochemical Manufacturing: Used in the synthesis of fluorinated pesticides and herbicides, where its properties enhance product stability and efficacy.
• Polymer & Material Science: Acts as a catalyst and solvent in the production of specialty polymers, including fluoropolymers and liquid crystal displays (LCDs).
• Organic Chemistry Reagent: Employed as a strong acid catalyst in various organic transformations, such as esterifications, rearrangements, and cyclizations.
• Analytical Chemistry: Utilized as a mobile phase modifier in liquid chromatography-mass spectrometry (LC-MS) due to its volatility and ion-pairing capabilities.
• Biochemistry & Proteomics: Applied in protein sequencing and analysis for the cleavage of peptides from solid supports and as a denaturing agent.

Basic Information

Product Name	Trifluoroacetic Acid
CAS No.	2173637-40-4
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; 2,2,2-Trifluoroacetic Acid; Acetic Acid, Trifluoro-; CF3COOH; NSC 77379; UN 2699
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and impurity profile analysis by gas chromatography (GC), to ensure it meets high-purity standards suitable for demanding synthetic applications. Certificates of Analysis (COA) documenting full specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat and incompatible materials such as strong bases and oxidizing agents. Due to its hygroscopic and highly volatile nature, containers should be kept tightly sealed and at a controlled room temperature (15-25°C).

Specification

Item	Specification
Appearance	Colorless Clear Liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Residue on Evaporation	≤ 0.005%
Chloride (Cl)	≤ 10 ppm
Sulfate (SO4)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.