Description

(2R)-2-Cyclobutyl-2-Hydroxyacetic Acid CAS NO 2165929-78-0 is a high-purity chiral building block of significant interest in advanced organic synthesis. Its value lies in the cyclobutyl moiety and the stereochemically defined hydroxyacetic acid functional group, which are crucial for modulating the physicochemical properties and biological activity of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in areas requiring constrained ring systems.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the cyclobutyl group can enhance metabolic stability and target specificity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioisosteres: The structure is valuable for designing peptide analogs and bioisosteric replacements in medicinal chemistry programs.
• Material Science Research: Potential monomer or additive for creating specialized polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Used to synthesize molecular probes for studying enzyme mechanisms or protein interactions.

Basic Information

Product Name	(2R)-2-Cyclobutyl-2-Hydroxyacetic Acid
CAS No.	2165929-78-0
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	(R)-2-Cyclobutyl-2-hydroxyacetic acid; (2R)-2-Cyclobutylglycolic acid; (R)-Cyclobutylhydroxyacetic acid; D-Cyclobutylhydroxyacetic acid; (R)-α-Hydroxycyclobutaneacetic acid; Cyclobutyl(hydroxy)acetic acid, (R)-; (2R)-2-Hydroxy-2-cyclobutylacetic acid; (R)-2-Hydroxy-2-cyclobutaneacetic acid
EINECS	Contact for details

Quality Control

Our (2R)-2-Cyclobutyl-2-Hydroxyacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.