Description

6,10-Dibenzyl-N,n-Dimethyl-N,N,N,n-Tetrakis(4-Methylbenzyl)-1,4-Dioxaspiro[4.5]Decane-(2S,3S)-Diylbis(Methylammonium) Bis(Tetrafluoroborate) [=(S,S)-Tadias-2Nd] is a sophisticated, chiral bis-ammonium salt catalyst of significant interest in advanced organic synthesis. Its value lies in its ability to act as a highly selective phase-transfer catalyst (PTC), enabling challenging asymmetric transformations under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries developing enantiomerically pure active ingredients and intermediates.

Application

• Asymmetric Phase-Transfer Catalysis (PTC): Enantioselective alkylation, Michael addition, and other C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Production of chiral building blocks for active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Fine Chemical Manufacturing: Synthesis of specialty chemicals, flavors, and fragrances where stereochemical control is critical.
• Academic and Industrial R&D: A key reagent for developing new catalytic methodologies in organic chemistry laboratories.
• Process Chemistry Optimization: Scaling up asymmetric reactions from laboratory to pilot plant and production scale.

Basic Information

Product Name	6,10-Dibenzyl-N,n-Dimethyl-N,N,N,n-Tetrakis(4-Methylbenzyl)-1,4-Dioxaspiro[4.5]Decane-(2S,3S)-Diylbis(Methylammonium) Bis(Tetrafluoroborate) [=(S,S)-Tadias-2Nd]
CAS No.	2135524-59-1
Molecular Formula	C62H78B2F8N2O2
Molecular Weight	1048.81 g/mol
Synonyms	(S,S)-Tadias-2Nd; (S,S)-Tadias-2Nd Tetrafluoroborate; (2S,3S)-Tadias-2Nd; (S,S)-2,2'-(1,4-Dioxaspiro[4.5]decane-2,3-diyl)bis(N,N,N-trimethyl-2-(4-methylbenzyl)ethan-1-aminium) bis(tetrafluoroborate); Chiral Bis-Ammonium Salt Catalyst; Asymmetric Phase Transfer Catalyst PTC; (S,S)-6,10-Dibenzyl-2,3-bis[(4-methylbenzyl)(trimethyl)ammoniomethyl]-1,4-dioxaspiro[4.5]decane bis(tetrafluoroborate)
EINECS	Contact for details

Quality Control

Every batch of our (S,S)-Tadias-2Nd is manufactured and tested under strict quality management protocols to ensure high purity and consistent catalytic performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.