Description

Sodium 5-(Trifluoromethyl)Pyridine-2-Sulfinate is a high-value organosulfur building block and nucleophilic sulfinate reagent. This compound is critical for introducing the versatile 5-(trifluoromethyl)pyridyl-2-sulfonyl moiety into target molecules, enabling the synthesis of complex sulfones and sulfonamides. It is primarily sought after by pharmaceutical, agrochemical, and advanced materials researchers for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of sulfonamide and sulfone-based drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethylpyridine scaffold confers enhanced bioactivity and metabolic stability.
• Material Science: Serves as a precursor for functionalized ligands and monomers in the creation of specialty polymers, metal-organic frameworks (MOFs), and electronic materials.
• Cross-Coupling Reactions: Acts as a nucleophilic sulfinate partner in transition-metal catalyzed cross-couplings (e.g., with aryl halides) for efficient C-S bond formation.
• Sulfone Library Synthesis: Enables high-throughput parallel synthesis for creating diverse sulfone-focused compound libraries in drug discovery.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes containing the sulfonyl group for studying protein function and enzyme inhibition.

Basic Information

Product Name	Sodium 5-(Trifluoromethyl)Pyridine-2-Sulfinate
CAS No.	2098851-48-8
Molecular Formula	C6H3F3NNaO2S
Molecular Weight	233.14 g/mol
Synonyms	Sodium 5-(trifluoromethyl)pyridine-2-sulfinate; 2-Pyridinesulfinic acid, 5-(trifluoromethyl)-, sodium salt (1:1); 5-(Trifluoromethyl)pyridine-2-sulfinic acid sodium salt; Sodium 5-(trifluoromethyl)-2-pyridinesulfinate; 5-Trifluoromethylpyridine-2-sulfinic Acid Sodium Salt; 2-Sulfinato-5-(trifluoromethyl)pyridine Sodium Salt; 5-CF3-Pyridine-2-SO2Na
EINECS	Contact for details

Quality Control

Our Sodium 5-(Trifluoromethyl)Pyridine-2-Sulfinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with customer specifications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.