Description

(S)-8-Chlorochroman-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its specific stereochemistry and functional groups, making it a critical precursor in the synthesis of targeted active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Serves as a versatile building block in enantioselective synthesis for constructing complex molecules with high optical purity.
• Agrochemical Research: Used in the development of new pesticides and herbicides where specific stereochemistry influences biological activity.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for probe molecule development.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Catalyst and Ligand Development: Potential precursor for novel chiral catalysts or ligands used in homogeneous catalysis.

Basic Information

Product Name	(S)-8-Chlorochroman-4-Amine Hydrochloride
CAS No.	2061996-42-5
Molecular Formula	C9H11Cl2NO
Molecular Weight	236.10 g/mol
Synonyms	(4S)-8-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; (S)-8-Chloro-3,4-dihydro-2H-chromen-4-amine hydrochloride; (S)-8-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine HCl; 8-Chloro-(4S)-chroman-4-amine hydrochloride; (S)-8-Chlorochroman-4-amine HCl; (4S)-8-Chlorochroman-4-amine hydrochloride; (S)-8-Chloro-3,4-dihydro-2H-chromen-4-amine HCl salt
EINECS	Contact for details

Quality Control

Our (S)-8-Chlorochroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.