Description

(2R)-Ethyl 2-Hydroxy-3-(2-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Phenyl)Propanoate is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its core value lies in its protected diol functionality and stereochemical integrity, which are critical for constructing complex molecular architectures with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially those requiring specific stereochemistry for biological activity.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce stereocenters.
• Natural Product Synthesis: Serves as a building block for the total synthesis of complex natural products with phenylpropanoate or diol motifs.
• Agrochemical Research: Employed in the development of new chiral pesticides and herbicides where stereoselectivity impacts efficacy.
• Ligand and Catalyst Development: Useful for preparing novel chiral ligands or organocatalysts for use in enantioselective transformations.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic chemistry and for scaling up synthetic routes in process R&D.

Basic Information

Product Name	(2R)-Ethyl 2-Hydroxy-3-(2-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Phenyl)Propanoate
CAS No.	2056887-68-2
Molecular Formula	C₁₆H₂₂O₅
Molecular Weight	294.34 g/mol
Synonyms	Ethyl (2R)-2-hydroxy-3-[2-(oxan-2-yloxy)phenyl]propanoate; (R)-Ethyl 2-hydroxy-3-(2-(tetrahydro-2H-pyran-2-yloxy)phenyl)propanoate; THP-protected (R)-Ethyl 2-hydroxy-3-(2-hydroxyphenyl)propanoate; (2R)-Ethyl 2-Hydroxy-3-(2-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Phenyl)Propionate; (R)-Ethyl 2-hydroxy-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)propanoate; (R)-Ethyl 2-hydroxy-3-(2-(THP-oxy)phenyl)propanoate; CAS 2056887-68-2
EINECS	Contact for details

Quality Control

Our (2R)-Ethyl 2-Hydroxy-3-(2-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Phenyl)Propanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.