Description

m-Peg3-S-Peg3-T-Butyl Ester is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a thioether linkage and a protected carboxylic acid terminus. This compound is engineered to serve as a critical building block in bioconjugation and pharmaceutical linker chemistry, offering controlled reactivity and enhanced solubility. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing targeted drug delivery systems, diagnostic agents, and functionalized biomaterials.

Application

• Bioconjugation Linker: Used to covalently attach therapeutic payloads (e.g., cytotoxic drugs, imaging agents) to targeting molecules like antibodies, peptides, or proteins.
• PEGylation Reagent: Serves as a functionalized PEG spacer to improve the pharmacokinetic properties, solubility, and stability of biologic drugs.
• Proteolysis-Targeting Chimera (PROTAC) Synthesis: Acts as a flexible linker component connecting the E3 ligase ligand and the target protein ligand in bifunctional degrader molecules.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, or solid supports to create biocompatible surfaces for diagnostic or therapeutic applications.
• Cross-linking Agent: Facilitates the formation of stable conjugates between biomolecules in diagnostic assay development and biosensor fabrication.
• Polymer Chemistry: Utilized as a monomer or macromonomer in the synthesis of advanced, stimuli-responsive polymeric materials for controlled release.

Basic Information

Item	Details
Product Name	m-Peg3-S-Peg3-T-Butyl Ester
CAS No.	2055040-96-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,11-Bis(2-(2-(2-methoxyethoxy)ethoxy)ethylthio)-3,6,9-trioxaundecane-11-oic acid tert-butyl ester; tert-Butyl 3,6,9,12,15,18,21-heptaoxa-24-thiatetracosane-1-carboxylate; Heterobifunctional PEG, Thio-PEG3-t-butyl ester; mPEG3-S-PEG3-t-Butyl ester; PEG-based heterobifunctional crosslinker
EINECS	Contact for details

Quality Control

Our m-Peg3-S-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) detailing purity, identity, and relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.