Description

Chloro(4-Cyanophenyl){(R)-1-[(S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyl (Diphenylphosphine)}Nickel(II) is a highly specialized, chiral nickel(II) complex featuring a ferrocenyl-based phosphine ligand, designed for advanced catalytic applications. Its core value lies in its ability to act as a precise and efficient catalyst for asymmetric transformations, enabling the synthesis of complex, enantiomerically pure molecules. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance catalysts for challenging synthetic routes.

Application

• Asymmetric Cross-Coupling Reactions: A key catalyst for enantioselective C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Kumada couplings.
• Pharmaceutical Intermediate Synthesis: Enables the production of chiral intermediates for active pharmaceutical ingredients (APIs) with high stereoselectivity.
• Agrochemical Product Development: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Advanced Material Science: Facilitates the creation of chiral polymers and ligands for novel material applications.
• Academic & Industrial R&D: A valuable tool for method development and exploring new catalytic pathways in organic synthesis.
• Process Chemistry Optimization: Employed to scale up and optimize catalytic processes for commercial manufacturing.

Basic Information

Item	Details
Product Name	Chloro(4-Cyanophenyl){(R)-1-[(S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyl (Diphenylphosphine)}Nickel(II)
CAS No.	2049086-36-2
Molecular Formula	C47H46ClFeNPP2Ni
Molecular Weight	857.81 g/mol
Synonyms	Nickel(II) chloro(4-cyanophenyl)((R)-1-((S)-2-(dicyclohexylphosphino)ferrocenyl)ethyl(diphenylphosphine)); Chiral Ferrocenyl Nickel Catalyst; Josiphos-type Nickel Complex; (R,S)-PPF-Nickel(II) Chloro(4-cyanophenyl) Complex; Asymmetric Nickel Catalyst; Nickel(II) complex with Josiphos ligand derivative; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyl(diphenylphosphine)chloro(4-cyanophenyl)nickel(II)
EINECS	Contact for details

Quality Control

Every batch of our chiral nickel catalyst is produced and tested under strict quality protocols to ensure exceptional purity and catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity, metal content, and ligand integrity. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries, ensuring traceability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This compound is moisture-sensitive and easily oxidized; prolonged exposure to air, light, or ambient humidity should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Nickel Content	6.5 - 7.2 %
Moisture Content (KF)	≤ 0.5 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.