Description

3-Morpholino-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is a sophisticated organosilicon reagent and a key triflate ester derivative used in advanced organic synthesis. Its value lies in its dual functionality, combining a protected amine group (morpholino) and a highly reactive triflate leaving group, which is crucial for facilitating challenging cross-coupling and nucleophilic substitution reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecular architectures and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing morpholine or aryl silane motifs.
• Cross-Coupling Reactions: Acts as an excellent electrophilic partner in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Stille, and Negishi couplings, due to the reactive phenyl triflate group.
• Nucleophilic Substitution: The trifluoromethanesulfonate (triflate) group is a superior leaving group, enabling efficient nucleophilic aromatic substitution under mild conditions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the morpholino and silane functionalities are required.
• Material Science Precursor: Employed in the development of organic electronic materials and functional polymers that incorporate silicon and heterocyclic amine groups.
• Protecting Group Strategy: The trimethylsilyl group can act as a temporary protecting group for the ortho-position, allowing for sequential functionalization of the aromatic ring.

Basic Information

Product Name	3-Morpholino-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
CAS No.	2047348-50-3
Molecular Formula	C14H20F3NO4SSi
Molecular Weight	383.46 g/mol
Synonyms	[2-(Trimethylsilyl)-3-morpholinophenyl] trifluoromethanesulfonate; 3-Morpholino-2-(trimethylsilyl)phenyl triflate; 2-(Trimethylsilyl)-3-morpholinophenyl triflate; Trifluoromethanesulfonic acid 3-morpholino-2-(trimethylsilyl)phenyl ester; 3-Morpholino-2-trimethylsilylphenyl triflate; CAS 2047348-50-3
EINECS	Contact for details

Quality Control

Our 3-Morpholino-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of process chemistry and regulatory starting material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong acids and should be kept away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.