Description

Isoxazole, 4-(Tributylstannyl)- is a specialized organotin reagent featuring a functionalized isoxazole heterocycle. This compound is a critical building block in modern synthetic organic chemistry, particularly for Stille cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules. CAS No. 2020067-63-2.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those containing the isoxazole pharmacophore for anti-inflammatory, antimicrobial, or anticancer activity.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides by introducing the isoxazole moiety into target molecules via palladium-catalyzed coupling.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of organic semiconductors, liquid crystals, and polymers with tailored electronic or optical properties.
• Stille Cross-Coupling Reactions: Acts as a versatile organotin nucleophile to form new carbon-carbon bonds with a wide variety of organic electrophiles (e.g., aryl halides, vinyl halides).
• Ligand and Catalyst Development: Employed in the preparation of novel metal-organic complexes and catalysts where the isoxazole ring acts as a coordinating ligand.
• Chemical Biology Probes: Useful for labeling or modifying biomolecules in research applications due to its selective reactivity.

Basic Information

Product Name	Isoxazole, 4-(Tributylstannyl)-
CAS No.	2020067-63-2
Molecular Formula	C15H29NOSn
Molecular Weight	374.10 g/mol
Synonyms	4-(Tributylstannyl)isoxazole; Tributyl(4-isoxazolyl)stannane; 4-Stannylisoxazole; Stannane, tributyl(4-isoxazolyl)-; 4-(Tributyltin)isoxazole; Isoxazole-4-tributyltin; Organotin reagent 2020067-63-2
EINECS	Contact for details

Quality Control

Every batch of Isoxazole, 4-(Tributylstannyl)- is manufactured and tested under strict quality management protocols. We ensure high purity and consistency through advanced analytical techniques including NMR (1H, 13C, 119Sn), HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95%
1H NMR Assay	Conforms
Tin (Sn) Content	31.0 - 32.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.