Description

6-Methoxy-3-[4-(Trifluoromethyl)Phenyl][1,2,4]Triazolo[4,3-B]Pyridazine is a high-value heterocyclic compound featuring a fused triazolopyridazine core, a methoxy substituent, and a trifluoromethylphenyl group. This specific molecular architecture makes it a critical advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in areas targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, or insecticides, leveraging the biological activity of the triazolopyridazine scaffold.
• Material Science: Investigated for incorporation into organic electronic materials, such as OLEDs or semiconductors, due to its conjugated system and electron-withdrawing trifluoromethyl group.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Chemical Biology Probe: Utilized in the development of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	6-Methoxy-3-[4-(Trifluoromethyl)Phenyl][1,2,4]Triazolo[4,3-B]Pyridazine
CAS No.	289651-70-3
Molecular Formula	C14H9F3N4O
Molecular Weight	306.25 g/mol
Synonyms	6-Methoxy-3-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine; 3-(4-Trifluoromethylphenyl)-6-methoxy-[1,2,4]triazolo[4,3-b]pyridazine; 6-Methoxy-3-(4-trifluoromethylphenyl)-[1,2,4]triazolo[4,3-b]pyridazine; [1,2,4]Triazolo[4,3-b]pyridazine, 6-methoxy-3-[4-(trifluoromethyl)phenyl]-; 289651-70-3; 6-Methoxy-3-(α,α,α-trifluoro-p-tolyl)-[1,2,4]triazolo[4,3-b]pyridazine
EINECS	Contact for details

Quality Control

Our 6-Methoxy-3-[4-(Trifluoromethyl)Phenyl][1,2,4]Triazolo[4,3-B]Pyridazine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant industry guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.