Description

1-(Pyridin-2-Yl)-n-[(1R,2R)-2-{[(Pyridin-2-Yl)Methylidene]Amino}Cyclohexyl]Methanimine is a sophisticated chiral ligand featuring a bis-imine structure derived from a trans-1,2-diaminocyclohexane backbone. This compound is of significant value in asymmetric catalysis and coordination chemistry, where its rigid, well-defined geometry is crucial for inducing high enantioselectivity in synthetic transformations. It is primarily sought by pharmaceutical intermediates manufacturers and advanced fine chemical research laboratories developing novel catalytic processes.

Application

• Asymmetric Catalysis: As a key chiral ligand for transition metals (e.g., Ru, Rh, Ir) in enantioselective hydrogenation, transfer hydrogenation, and C-C bond-forming reactions.
• Pharmaceutical Synthesis: Used in the production of enantiomerically pure active pharmaceutical ingredients (APIs) and complex drug intermediates.
• Material Science Research: Serves as a building block for constructing chiral metal-organic frameworks (MOFs) and other functional coordination polymers.
• Academic & Industrial R&D: A valuable reagent for method development in organic synthesis and catalysis studies within university and corporate research labs.
• Agrochemical Intermediates: Potential application in the synthesis of chiral pesticides and herbicides requiring specific stereochemistry for efficacy.
• Ligand Library Development: A component in high-throughput screening libraries for discovering new catalytic systems.

Basic Information

Item	Detail
Product Name	1-(Pyridin-2-Yl)-n-[(1R,2R)-2-{[(Pyridin-2-Yl)Methylidene]Amino}Cyclohexyl]Methanimine
CAS No.	284497-48-9
Molecular Formula	C19H21N5
Molecular Weight	319.41 g/mol
Synonyms	(1R,2R)-N1,N2-Bis(pyridin-2-ylmethylene)cyclohexane-1,2-diamine; (R,R)-N,N'-Bis(2-pyridylmethylene)-1,2-diaminocyclohexane; (R,R)-DACH-Bis(2-Pyridinecarboxaldimine); (R,R)-1,2-Bis[(pyridin-2-yl)methylideneamino]cyclohexane; (R,R)-Jacobsen's Ligand Derivative; Chiral Bis(imine) Ligand; trans-N,N'-Bis(2-pyridylmethylidene)-1,2-diaminocyclohexane
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal performance in catalytic applications. Each lot is characterized using advanced analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry to confirm identity, enantiomeric excess (ee), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and opened under dry, inert conditions when necessary to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.