Description

4,5-Pyridazinediol,1,4,5,6-Tetrahydro-3-(Hydroxymethyl)-,(4R,5R)-(9Ci) is a high-purity chiral pyridazine derivative, a crucial advanced pharmaceutical intermediate (API) and building block in organic synthesis. Its defined stereochemistry and functional groups make it a valuable precursor for developing novel, targeted therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Drug Discovery & Development: Serves as a core building block for medicinal chemistry programs, particularly in creating libraries of compounds for biological screening.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective synthesis due to its fixed (4R,5R) configuration.
• Biochemical Research: Used in the study of enzyme inhibitors or as a ligand precursor in catalyst development.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring high stereochemical purity.

Basic Information

Product Name	4,5-Pyridazinediol,1,4,5,6-Tetrahydro-3-(Hydroxymethyl)-,(4R,5R)-(9Ci)
CAS No.	280772-08-9
Molecular Formula	C6H10N2O3
Molecular Weight	158.16 g/mol
Synonyms	(4R,5R)-1,4,5,6-Tetrahydro-3-(hydroxymethyl)-4,5-pyridazinediol; (4R,5R)-Tetrahydro-3-(hydroxymethyl)-4,5-pyridazinediol; 1,4,5,6-Tetrahydro-3-(hydroxymethyl)-4,5-pyridazinediol, (4R-cis)-; (4R,5R)-3-(Hydroxymethyl)-1,4,5,6-tetrahydro-4,5-pyridazinediol; cis-(4R,5R)-Tetrahydro-3-(hydroxymethyl)-4,5-pyridazinediol; Pyridazinediol derivative (4R,5R); CAS 280772-08-9
EINECS	Contact for details

Quality Control

Every batch of 4,5-Pyridazinediol,1,4,5,6-Tetrahydro-3-(Hydroxymethyl)-,(4R,5R)-(9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) with specifications for assay, chiral purity, and related substances is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.