Description

2-Amino-4-Isobutyl-5-Oxo-5,6,7,8-Tetrahydro-4H-Chromene-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring chromene structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new therapeutic agents and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory agents.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic scaffold for bioactivity.
• Organic Synthesis Building Block: Employed in complex multi-step organic syntheses to construct fused polycyclic systems for material science and catalysis research.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing specialized chromophores and functional dyes due to its chromene core.
• Academic & Contract Research: Essential for medicinal chemistry programs in academic institutions and contract research organizations (CROs) exploring structure-activity relationships (SAR).

Basic Information

Product Name	2-Amino-4-Isobutyl-5-Oxo-5,6,7,8-Tetrahydro-4H-Chromene-3-Carbonitrile
CAS No.	275360-58-2
Molecular Formula	C₁₄H₂₀N₂O₂
Molecular Weight	248.32 g/mol
Synonyms	4H-Chromene-3-carbonitrile, 2-amino-5,6,7,8-tetrahydro-4-(2-methylpropyl)-5-oxo-; 2-Amino-4-isobutyl-5-oxo-4,5,6,7,8,9-hexahydro-1-benzopyran-3-carbonitrile; 2-Amino-4-isobutyl-5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyran-3-carbonitrile; 4H-1-Benzopyran-3-carbonitrile, 2-amino-5,6,7,8-tetrahydro-4-(2-methylpropyl)-5-oxo-; Tetrahydrochromene Carbonitrile Derivative; AIBTC; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 2-Amino-4-Isobutyl-5-Oxo-5,6,7,8-Tetrahydro-4H-Chromene-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.