Description

2,4-Difluorophenyl Trifluoromethanesulfonate is a high-purity, specialty fluorinated building block essential for advanced organic synthesis. This compound is valued for its excellent leaving group properties, enabling efficient nucleophilic aromatic substitution and cross-coupling reactions to introduce the 2,4-difluorophenyl moiety. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluorophenyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized fluorinated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Employed in the synthesis of fluorinated monomers and polymers for specialty plastics, coatings, and electronic materials with enhanced properties.
• Cross-Coupling Reactions: An effective electrophile in Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The triflate group is an excellent leaving group for reactions with various nucleophiles, including amines, alkoxides, and thiols.

Basic Information

Item	Detail
Product Name	2,4-Difluorophenyl Trifluoromethanesulfonate
CAS No.	264135-49-1
Molecular Formula	C7H3F5O3S
Molecular Weight	262.15 g/mol
Synonyms	2,4-Difluorophenyl Triflate; 2,4-Difluorophenyl Trifluoromethanesulphonate; 2,4-Difluorophenyl Trifluoromethylsulfonate; (2,4-Difluorophenyl) Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid 2,4-Difluorophenyl Ester; 2,4-DFPT; 2,4-Difluorophenyl Tosylate Analog (Fluorinated)
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluorophenyl Trifluoromethanesulfonate is manufactured and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, is performed to guarantee identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.