Description

4-(Dimethylphenylsilyl)-3-Butyn-2-One is a specialized organosilicon building block featuring both a silyl-protected alkyne and a ketone functional group. This unique bifunctional structure makes it a valuable intermediate for constructing complex molecular architectures in advanced synthetic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of novel silicon-containing compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing silicon or constructing complex alkyne-containing scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive functional groups for structural diversification.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers, resins, and silicon-based hybrid materials.
• Organic Synthesis Building Block: Employed in Sonogashira, Hiyama, and other transition-metal-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Useful for preparing novel organosilicon ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic and R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic pathways in organic and organometallic chemistry.

Basic Information

Item	Detail
Product Name	4-(Dimethylphenylsilyl)-3-Butyn-2-One
CAS No.	263914-93-8
Molecular Formula	C12H14OSi
Molecular Weight	202.33 g/mol
Synonyms	1-(Dimethyl(phenyl)silyl)but-2-yn-1-one; 3-Butyn-2-one, 4-(dimethylphenylsilyl)-; Dimethyl(phenyl)silylacetyl methyl ketone; (Dimethylphenylsilyl)butynone; Phenyl(dimethyl)silylbutynone; 4-Dimethylphenylsilyl-3-butyn-2-one; 1-(Dimethylphenylsilyl)-3-butyn-2-one
EINECS	Contact for details

Quality Control

Every batch of 4-(Dimethylphenylsilyl)-3-Butyn-2-One is produced and tested under strict quality management protocols to ensure consistency and purity for research and development applications. Our standard analytical suite includes identification, purity assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.