Description

Benzene, 2-(Bromomethyl)-4-Chloro-3-Fluoro-1-(Trifluoromethyl)- is a highly functionalized halogenated benzene derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring bromomethyl, chloro, fluoro, and trifluoromethyl substituents, makes it an exceptionally versatile building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen and trifluoromethyl groups contribute to biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromomethyl group is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Fluorine Chemistry Research: An important substrate for studying the effects of multiple halogen substitutions on chemical reactivity and physical properties in academic and industrial R&D settings.
• Ligand and Catalyst Development: Used to synthesize novel chelating ligands and organocatalysts for asymmetric synthesis and metal complexation.

Basic Information

Product Name	Benzene, 2-(Bromomethyl)-4-Chloro-3-Fluoro-1-(Trifluoromethyl)-
CAS No.	261763-10-4
Molecular Formula	C9H4BrClF4
Molecular Weight	295.48 g/mol
Synonyms	2-(Bromomethyl)-4-chloro-3-fluoro-1-(trifluoromethyl)benzene; 1-Bromo-2-(bromomethyl)-4-chloro-3-fluoro-5-(trifluoromethyl)benzene (common misnomer); 4-Chloro-3-fluoro-2-(bromomethyl)-1-(trifluoromethyl)benzene; α-Bromo-4-chloro-3-fluoro-2-methylbenzotrifluoride; (Bromomethyl)-4-chloro-3-fluoro-1-(trifluoromethyl)benzene; Halogenated Benzotrifluoride Intermediate; BTFP-Br derivative
EINECS	Contact for details

Quality Control

Our production of Benzene, 2-(Bromomethyl)-4-Chloro-3-Fluoro-1-(Trifluoromethyl)- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with global regulatory frameworks, including REACH, and can prepare documentation for pharmaceutical applications under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.