Description

2,3:5,6-Bis-o-(1-Methylethylidene)-D-Gulose Oxime is a specialized, high-purity chiral intermediate derived from D-gulose, featuring protected diol groups. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostics, and advanced chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in nucleoside and carbohydrate-based drug discovery.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce specific stereocenters into target molecules.
• Glycochemistry Research: Serves as a protected sugar derivative for studying glycosylation reactions and synthesizing complex oligosaccharides or glycoconjugates.
• Ligand and Catalyst Development: Employed in the design and synthesis of chiral ligands for metal catalysis or organocatalysts.
• Chemical Biology Probes: Utilized to create labeled or modified sugar analogs for investigating biological recognition and metabolic pathways.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic synthesis and stereochemistry.

Basic Information

Product Name	2,3:5,6-Bis-o-(1-Methylethylidene)-D-Gulose Oxime
CAS No.	260441-81-4
Molecular Formula	C₁₂H₂₁NO₆
Molecular Weight	275.30 g/mol
Synonyms	D-Gulose, 2,3:5,6-bis-O-(1-methylethylidene)-, oxime; 2,3:5,6-Di-O-isopropylidene-D-gulose oxime; (3aR,5R,6S,6aR)-5-[(1E)-Hydroxyimino]-2,2,5a-trimethyltetrahydrofuro[2,3-d][1,3]dioxole-6-methanol; Isopropylidene-D-gulose oxime; Protected D-gulose oxime derivative
EINECS	Contact for details

Quality Control

Our 2,3:5,6-Bis-o-(1-Methylethylidene)-D-Gulose Oxime is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. Each lot is characterized by modern analytical techniques including NMR, HPLC, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Optical Rotation	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.