Description

6,8-Difluorochroman-4-One is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoro substitution pattern is crucial for modulating biological activity and metabolic stability. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors engaged in the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atoms enhance lipophilicity and target binding.
• Material Science Research: Serves as a building block for creating fluorinated organic frameworks and advanced polymers with unique properties.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Academic & R&D: Utilized in university and corporate research labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	6,8-Difluorochroman-4-One
CAS No.	259655-01-1
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	6,8-Difluoro-4-chromanone; 4H-1-Benzopyran-4-one, 6,8-difluoro-2,3-dihydro-; 6,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-one; 6,8-Difluoro-2,3-dihydro-4H-chromen-4-one; 6,8-Difluorochromanone; 6,8-Difluoro-4-chromone (common misnomer); 259655-01-1 (CAS Registry)
EINECS	Contact for details

Quality Control

Our 6,8-Difluorochroman-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.