Description

(3R,5S)-5-(Hydroxymethyl)Tetrahydrofuran-3-Ol CAS NO 259539-06-5 is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. This compound is crucial for the stereoselective synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate its defined stereochemistry into their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of nucleoside analogs, antiviral drugs, and other bioactive molecules.
• Asymmetric Synthesis: Used as a starting material or precursor in catalytic asymmetric reactions to construct complex stereocenters.
• Fine Chemical Production: Serves as a building block for fragrances, flavors, and advanced materials requiring specific optical purity.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where stereochemistry affects biological activity.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic synthesis and scale-up process optimization.

Basic Information

Product Name	(3R,5S)-5-(Hydroxymethyl)Tetrahydrofuran-3-Ol
CAS No.	259539-06-5
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	(3R,5S)-Tetrahydro-5-(hydroxymethyl)-3-furanol; (3R,5S)-5-(Hydroxymethyl)tetrahydro-3-furanol; (3R-cis)-Tetrahydro-5-(hydroxymethyl)-3-furanol; cis-5-(Hydroxymethyl)tetrahydrofuran-3-ol; (3R,5S)-Isomer of Tetrahydro-5-(hydroxymethyl)-3-furanol
EINECS	Contact for details

Quality Control

Our (3R,5S)-5-(Hydroxymethyl)Tetrahydrofuran-3-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.