Description

2-(1-Oxy-Pyridin-2-Yl)-1,1,3,3-Tetramethylisothiouronium Tetrafluoroborate is a specialized organic salt primarily used as a high-performance coupling reagent and catalyst in advanced synthetic chemistry. Its value lies in its ability to facilitate challenging amide bond formations and other condensation reactions with high efficiency and minimal racemization, which is critical for producing pure, complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for peptide synthesis and heterocyclic chemistry.

Application

• Peptide Synthesis: As an effective coupling agent for the formation of amide bonds in solid-phase and solution-phase peptide synthesis, minimizing epimerization.
• Pharmaceutical Intermediates: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex amide and heterocyclic cores.
• Agrochemical Production: Used in the manufacture of certain herbicides and fungicides where specific amide linkages are required.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in developing new synthetic routes and optimizing reaction conditions.
• Material Science: Potential application in the synthesis of functional polymers and dendrimers that require precise amide coupling steps.
• Bioconjugation: Facilitating the linkage of small molecules to proteins, antibodies, or other biomolecules for diagnostic and therapeutic applications.

Basic Information

Product Name	2-(1-Oxy-Pyridin-2-Yl)-1,1,3,3-Tetramethylisothiouronium Tetrafluoroborate
CAS No.	255825-38-8
Molecular Formula	C12H20BF4N3OS
Molecular Weight	341.18 g/mol
Synonyms	2-(1-Oxidopyridin-1-ium-2-yl)-1,1,3,3-tetramethylisothiouronium Tetrafluoroborate; TOTT; PyO-TOTT; 2-(1-Oxypyridin-2-yl)-1,1,3,3-tetramethylisothiouronium Tetrafluoroborate; 2-(1-Oxido-2-pyridinyl)-1,1,3,3-tetramethylisothiouronium Tetrafluoroborate; Tetramethylisothiouronium Salt of 2-(1-Oxypyridin-2-yl); Coupling Reagent TOTT; HOTT Analog
EINECS	Contact for details

Quality Control

Our production of 2-(1-Oxy-Pyridin-2-Yl)-1,1,3,3-Tetramethylisothiouronium Tetrafluoroborate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to support cGMP compliance for pharmaceutical intermediate use, and we welcome audits and specific quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in polar organic solvents (e.g., DMF, DMSO, acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.