Description

4-Methoxyphenylzinc Iodide is a versatile organozinc reagent, specifically an arylzinc halide, widely used in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation through cross-coupling reactions, offering excellent functional group tolerance and selectivity. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a key building block for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for the Negishi and related cross-coupling reactions to introduce the 4-methoxyphenyl moiety into drug candidate molecules.
• Agrochemical Production: Used in the synthesis of active ingredients and fine chemicals for crop protection products.
• Ligand and Catalyst Development: Serves as a precursor in the preparation of specialized ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED and OFET components, where the methoxyphenyl group modifies electronic properties.
• Fine Chemical and Flavor/Fragrance Synthesis: Facilitates the construction of complex aromatic structures found in specialty chemicals.
• Academic and R&D Laboratories: A valuable tool for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	4-Methoxyphenylzinc Iodide
CAS No.	254454-47-2
Molecular Formula	C7H7IOZn
Molecular Weight	299.41 g/mol
Synonyms	(4-Methoxyphenyl)zinc iodide; p-Methoxyphenylzinc iodide; Zinc, (4-methoxyphenyl)iodo-; 4-Methoxybenzenezinc iodide; 4-Anisylzinc iodide; 4-MeOC6H4ZnI
EINECS	Contact for details

Quality Control

Our 4-Methoxyphenylzinc Iodide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and solution concentration (typically supplied in THF or ether). We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay, residual moisture, and metal impurities. Our quality management system supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), this reagent must be stored under an inert gas (argon or nitrogen) in a cool, dry place. For extended stability, storage at 2-8°C is recommended. The solution is highly volatile and flammable; keep away from heat, sparks, and open flame. Use appropriate ventilation and chemical handling procedures.

Specification

Item	Specification
Appearance (Solution)	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (relative area)
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.