Description

(2S)-3-(4-Hydroxyphenyl)-4-Methyl-2-[4-[2-(1-Piperidyl)Ethoxy]Phenyl]-2H-Chromen-7-Ol CAS NO 252555-01-4 is a high-purity, non-racemic chromene derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a sophisticated chiral building block and a potential active pharmaceutical ingredient (API) intermediate, offering precise stereochemical control for creating novel therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors working on selective estrogen receptor modulators (SERMs) and other targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of advanced drug candidates, particularly in oncology and endocrine disorder research.
• Biochemical Research: Used as a reference standard and probe compound in studies of estrogen receptor biology and signal transduction pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex, stereochemically defined molecules.
• Analytical Standard: Provides a high-purity benchmark for method development and validation in quality control laboratories (e.g., HPLC, chiral analysis).
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to explore and optimize biological activity profiles of chromene-based compounds.
• Custom Synthesis: Acts as a starting material for the contract manufacturing of specialized APIs and novel chemical entities (NCEs).

Basic Information

Product Name	(2S)-3-(4-Hydroxyphenyl)-4-Methyl-2-[4-[2-(1-Piperidyl)Ethoxy]Phenyl]-2H-Chromen-7-Ol
CAS No.	252555-01-4
Molecular Formula	C29H31NO4
Molecular Weight	457.57 g/mol
Synonyms	Bazedoxifene Impurity; (S)-Bazedoxifene; (2S)-Bazedoxifene; TSE-424; WAY-140424; (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]chromen-7-ol; 7-Hydroxy-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidinoethoxy)phenyl]-2H-1-benzopyran, (S)-; UNII-8V32U4IVQU (component)
EINECS	Contact for details

Quality Control

Our (2S)-3-(4-Hydroxyphenyl)-4-Methyl-2-[4-[2-(1-Piperidyl)Ethoxy]Phenyl]-2H-Chromen-7-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.