Description

Boc-Aminooxy-Peg2-Amine CAS NO 252378-69-1 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected aminooxy group and a primary amine. This compound is a critical reagent for bioconjugation and chemical biology, enabling the site-specific attachment of biomolecules under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing antibody-drug conjugates (ADCs), peptide modifications, and advanced polymer therapeutics.

Application

• Key reagent for the synthesis of antibody-drug conjugates (ADCs) and other targeted biotherapeutics.
• Site-specific protein and peptide modification via oxime ligation with carbonyl-containing molecules.
• Building block for creating PEGylated drug delivery systems and functionalized hydrogels.
• Crosslinker for surface functionalization in biosensor and diagnostic assay development.
• Intermediate in the synthesis of complex small molecule prodrugs with improved solubility.
• Tool compound for chemical biology research involving bioorthogonal chemistry.

Basic Information

Product Name	Boc-Aminooxy-Peg2-Amine
CAS No.	252378-69-1
Molecular Formula	C14H29N3O6
Molecular Weight	335.40 g/mol
Synonyms	1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid 15-[(1,1-dimethylethoxy)imino] ester; 2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl (tert-butoxycarbonylaminooxy)acetate; Boc-NH-O-PEG2-NH2; Boc-Aminooxy-PEG2-Amine; tert-Butyl N-(17-amino-3,6,9,12-tetraoxa-16-oxoheptadecyloxy)carbamate; Amino-PEG2-Boc-Aminooxy; Heterobifunctional PEG linker Boc-Aminooxy-PEG2-Amine
EINECS	Contact for details

Quality Control

Our Boc-Aminooxy-Peg2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.