Description

1-(Trimethylsilyl)-2-Naphthyl Triflate is a specialized organosilicon reagent and a highly reactive triflate ester derivative. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for naphthalene-based compounds.
• Cross-Coupling Reactions: Serves as an effective electrophile in palladium-catalyzed reactions such as Suzuki, Negishi, and Stille couplings for carbon-carbon bond formation.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and other functional organic materials.
• Agrochemical Synthesis: Employed as an intermediate in creating novel herbicides, fungicides, and plant growth regulators.
• Organometallic Chemistry: Acts as a precursor for generating organometallic species used in catalysis and further synthetic transformations.
• Laboratory Reagent: Utilized in academic and industrial R&D settings for methodological development and scale-up studies.

Basic Information

Product Name	1-(Trimethylsilyl)-2-Naphthyl Triflate
CAS No.	252054-88-9
Molecular Formula	C₁₄H₁₇F₃O₃SSi
Molecular Weight	350.43 g/mol
Synonyms	2-[(Trimethylsilyl)naphthalen-1-yl] trifluoromethanesulfonate; 1-Naphthyltrimethylsilyl Triflate; 1-Trimethylsilyl-2-naphthyl Trifluoromethanesulfonate; 1-(Trimethylsilyl)-2-naphthyl Trifluoromethanesulfonate; 2-Naphthyltrimethylsilyl Triflate; TMS-Naphthyl Triflate; 1-TMS-2-Naphthyl OTf
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-2-Naphthyl Triflate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.