Description

5-Bromo-3-Fluorosalicylic Acid, also known as 4-Bromo-2-Carboxy-6-Fluorophenol, is a high-purity halogenated salicylic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both bromine and fluorine substituents on the aromatic ring, makes it an exceptionally versatile intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the halogen atoms contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized monomers for specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create fluorescent tags and molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A valuable scaffold for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	5-Bromo-3-Fluorosalicylic Acid
CAS No.	251300-29-5
Molecular Formula	C7H4BrFO3
Molecular Weight	235.01 g/mol
Synonyms	4-Bromo-2-Carboxy-6-Fluorophenol; 5-Bromo-3-fluoro-2-hydroxybenzoic acid; 2-Hydroxy-5-bromo-3-fluorobenzoic acid; 6-Fluoro-4-bromosalicylic acid; 4-Bromo-6-fluorosalicylic acid; 5-Bromo-3-fluorosalicylate; BAFF; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-3-Fluorosalicylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, residual solvent analysis, and identification by IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.